Serological Studies on Adult Volunteers Inoculated with Oil-adjuvant Asian Influenza Vaccine

Serological Studies on Adult Volunteers Inoculated with Oil-adjuvant Asian Influenza Vaccine. Report to the M.r.c. Committee on Influenza and Other Respiratory Virus Vaccines.

Monitoring virus harvesting time in embryonated chicken eggs inoculated with avian influenza H9N2 vaccine strain

Knowledge of virus and replication kinetic is one of the most important issues in the vaccine production. The present study aimed to evaluate the best harvesting time of H9N2 avian influenza virus (AIV) vaccine strain inoculated in specific pathogen free (SPF) embryonated chicken eggs (ECE)s. For this purpose, 10-5 dilution of AIV (A/Chicken/Iran/99/H9N2) was inoculated into 336, 11-day old ECE...

An adsorbed surface-antigen influenza vaccine and its serological activity in volunteers.

Introduction The purification of influenza virus vaccine has been facilitated by two major technological advances, namely the development of zonal rotors capable of processing large volumes ot fluid, and the application of surfactants, lipid solvents or proteases to disrupt the influenza virion. However, application of either of these two principles can still leave one with a vaccine which cont...

Near-Infrared Laser Adjuvant for Influenza Vaccine

Safe and effective immunologic adjuvants are often essential for vaccines. However, the choice of adjuvant for licensed vaccines is limited, especially for those that are administered intradermally. We show that non-tissue damaging, near-infrared (NIR) laser light given in short exposures to small areas of skin, without the use of additional chemical or biological agents, significantly increase...

Adjuvant solution for pandemic influenza vaccine production.

Extensive preparation is underway to mitigate the next pandemic influenza outbreak. New vaccine technologies intended to supplant egg-based production methods are being developed, with recombinant hemagglutinin (rHA) as the most advanced program for preventing seasonal and avian H5N1 Influenza. Increased efforts are being focused on adjuvants that can broaden vaccine immunogenicity against emer...